Nutritional Ketosis & Ketone Bodies Help Improve CVD Outcomes
Prevent or Reverse Heart Failure with the Keto Diet
Research from Saint Louis University has found the Keto Diet could completely prevent or possibly reverse heart failure caused by a metabolic process.
- Thus, these studies suggest that consumption of higher fat and lower carbohydrate diets may be a nutritional therapeutic intervention to treat heart failure.” – Kyle S. McCommis, Ph.D, Assistant Professor, Biochemistry and Molecular Biology, Saint Louis University
- Diets enriched with higher levels of fat but enough carbohydrate and protein to limit ketosis were also able to significantly improve or even prevent cardiac remodeling and dysfunction in a mouse model.
- These studies suggest that consumption of higher fat and lower carbohydrate diets may be a nutritional therapeutic intervention to treat heart failure.
- Like ketogenic diet, prolonged fasting increases the cardiac reliance on fatty acid oxidation and reduces ketolytic flux despite increased cardiac ketone body delivery. The 24-hour fast reduced blood glucose levels, and strongly enhanced plasma concentrations of non-esterified fatty acids and ketone bodies.
- Ketogenic diet consumption for only three weeks and the concordant increase in fat metabolism was associated with reverse remodeling of the failing hearts to essentially normal size.
- These results suggest that ketogenic diets do not enhance cardiac ketone body metabolism, but rather stimulates fatty acid oxidation, which may be responsible for the improved cardiac remodeling and performance.
Ketone Bodies Used in Treatment and Prevention of CVD (Cardiovascular Disease)
From the Journal of American College of Cardiology evidence has been found that ketone bodies may improve endothelial function, ameliorate oxidative stress, improve mitochondrial function, exert anti-inflammatory actions, and mitigate cardiac remodeling.
Evidence for benefits of ketone bodies in subjects with cardiovascular disease is rapidly emerging. In addition to the role of ketones in provision of an ancillary fuel for the failing heart, ketone bodies may also exert a myriad of pleiotropic effects. Ketone bodies may improve endothelial function, ameliorate oxidative stress, improve mitochondrial function, exert anti-inflammatory actions, and mitigate cardiac remodeling. Other systemic extracardiac effects on body weight, blood pressure, glycemia, and lipid profile may also benefit patients with CVD.
Cardiovascular Disease Risk Improvements in T2D Patients Following Nutritional Ketosis Guidelines
Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1 year: an open label, non-randomized, controlled study
A continuous care treatment including nutritional ketosis in patients with T2D improved most biomarkers of CVD risk after 1 year. The increase in LDL-cholesterol appeared limited to the large LDL subfraction. LDL particle size increased, total LDL-P and ApoB were unchanged, and inflammation and blood pressure decreased.
- Cardiovascular disease (CVD) is a leading cause of death among adults with type 2 diabetes mellitus (T2D).
- Glycemic control is vital while improving heart health outcomes.
- Nutritional Ketosis improves CVD biomarkers in T2D patients
The Keto Diet Helps Improve Type 2 Diabetes Outcomes
6 Year Review of a Low Carb Diet on Type 2 Diabetes Therapy
Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2
diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years
I’ve written more on the “Diabetes Cure” here. Citing this study as reference. Overview:
- A lower carbohydrate diet approach for patients with T2D and prediabetes can be effectively incorporated over a prolonged period (6 years).
- Glycemic control (as measured by HbA1c) is most influenced by the consumption of food with higher GI and glycemic loads, such as those containing simple sugars and starchy carbohydrates.
- Significant improvements were observed across all cardiometabolic parameters measured: weight, HbA1c, lipid profile and BP with drug-free T2D remission in 46% of all patients with T2D.
- Of the prediabetic patients, 93% attained a normal HbA1c and similar improvements in cardiometabolic markers
- Benefits included deprescribing of anti-diabetic medications.
Type 2 Diabetes Remission via Low Carb Diets
Published in January in the British Medical Journal (BMJ), scientists found that after six months, patients who followed a low carb diet containing less than 26 per cent of daily calories from carbohydrates achieved greater rates of type 2 diabetes remission than those who followed other diets traditionally recommended for managing the disease.
Professor Grant Brinkworth, contributing author to the study and CSIRO Research Scientist, said the findings showed those who better adhered to the low carb dietary approach had the greatest health improvements.
“Building on existing research, this study underscores that a low carb diet can achieve greater weight loss and is more effective in reducing diabetes medication and improving blood glucose control,” Professor Brinkworth said.
“However, this study has gone one step further in showing the low carb dietary approach to be effective in driving type 2 diabetes into remission.
“We know that lifestyle factors such as what we eat play a major part in determining our risk to type 2 diabetes. The good news is these lifestyle choices are within our control to change.”
65 YO Female Individual, Clinical Result of Reversing Type 2 Diabetes
The 12-week individualized treatment intervention served to functionally reverse 26 years of T2DM, ameliorate two and half decades of chronic depressive disorder and empower/equip the patient with a new experience of hope and success.
- 65-year old female who presented with a 26-year history of dually-diagnosed Type 2 diabetes.
- 12 week intervention.
- The patient’s HgA1c dropped out of diabetic range (8.0%) and normalized at 5.4%.
- Her average daily glucose measurements declined from 216 mg/dL to 96 mg/dL; the HOMA-IR and triglyceride/HDL ratios improved by 75%.
Carbohydrate Restriction Improves Metabolic Syndrome Outcomes
Low carb has favorable impact on metabolic syndrome (more than low fat)
- We recently proposed that the biological markers improved by carbohydrate restriction were precisely those that define the metabolic syndrome (MetS), and that the common thread was regulation of insulin as a control element.
- 12-week study comparing two hypocaloric diets (approximately 1,500 kcal): a carbohydrate-restricted diet (CRD) (%carbohydrate:fat:protein = 12:59:28) and a low-fat diet (LFD) (56:24:20) in 40 subjects with atherogenic dyslipidemia.
- Both interventions led to improvements in several metabolic markers, but subjects following the CRD had consistently reduced glucose (-12%) and insulin (-50%) concentrations, insulin sensitivity (-55%), weight loss (-10%), decreased adiposity (-14%), and more favorable triacylglycerol (TAG) (-51%), HDL-C (13%) and total cholesterol/HDL-C ratio (-14%) responses.
- In addition to these markers for MetS, the CRD subjects showed more favorable responses to alternative indicators of cardiovascular risk: postprandial lipemia (-47%), the Apo B/Apo A-1 ratio (-16%), and LDL particle distribution.
- Despite a threefold higher intake of dietary saturated fat during the CRD, saturated fatty acids in TAG and cholesterol ester were significantly decreased, as was palmitoleic acid (16:1n-7), an endogenous marker of lipogenesis, compared to subjects consuming the LFD.
- Serum retinol binding protein 4 has been linked to insulin-resistant states, and only the CRD decreased this marker (-20%).
- The results support the use of dietary carbohydrate restriction as an effective approach to improve features of MetS and cardiovascular risk.
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